%0 Journal Article
%T Childhood trauma and self-harm in youths with bipolar disorders
%J Current neuropharmacology
%D 2023
%A Janiri, Delfina
%A Di Luzio, Michelangelo
%A Montanari, Silvia
%A Hirsch, Daniele
%A Simonetti, Alessio
%A Moccia, Lorenzo
%A Conte, Eliana
%A Contaldo, Ilaria
%A Veredice, Chiara
%A Mercuri, Eugenio
%A Sani, Gabriele
%V ePub
%N ePub
%P ePub-ePub
%X BACKGROUND: Bipolar disorders (BD) in youth are associated with high risk of self-harm behaviors. Childhood trauma (CT) is a relevant environmental stressor that is related with both BD diagnosis and self-harm in adulthood. It is not yet established whether CT may impact on self-harm risk in youth. Therefore, the aim of this study was to investigate the distribution patterns of CT in youth BD with and without self-harm. <br><br>METHODS: We assessed 273 participants (aged 13-25 years), 96 youths with BD according to DSM-5 criteria and 177 healthy controls (HC). History of CT was obtained using the Childhood Trauma Questionnaire (CTQ). The association between CT and self-harm was tested using multivariate statistical models. <br><br>RESULTS: Over 45% of participants with BD reported lifetime self-harm. The BD Self-harm group reported more emotional abuse, emotional neglect, sexual abuse, and physical abuse than HC. The BD No-Self-harm group reported more emotional abuse than HC. The BD Self-harm group reported more emotional abuse and neglect than the BD No-Self-harm group, The BD Self-harm group also reported more separated parents, hospitalizations, smoking, use of antiepileptics, antipsychotics and lithium. Emotional abuse was an independent predictor of self-harm in youths with BD. <br><br>CONCLUSIONS: Findings support the importance of assessing CT, in particular emotional abuse, in youth with BD at risk for self-harm.<p /> <p>Language: en</p>
%G en
%I Bentham Science Publishers
%@ 1570-159X
%U http://dx.doi.org/10.2174/1570159X21666230213155249