%0 Journal Article
%T Deep brain stimulation may be a viable option for resistant to treatment aggression in children with intellectual disability
%J CNS neuroscience and therapeutics
%D 2023
%A Benedetti-Isaac, Juan Carlos
%A Camargo, Loida
%A Torres Zambrano, Martin
%A Perea-Castro, Esther
%A Castillo-Tamara, Edgard
%A Caldichoury, Nicole
%A Herrera-Pino, Jorge
%A Flórez, Yuliana
%A Porto, María
%A López, Norman
%V ePub
%N ePub
%P ePub-ePub
%X INTRODUCTION: Deep brain stimulation (DBS) is a surgical technique used to manage aggression in patients who do not improve despite the use of appropriate drug treatment. <br><br>OBJECTIVE: The objective of this study is to assess the impact of DBS on aggressive behavior refractory to the pharmacological and behavioral treatment of patients with Intellectual Disabilities (ID). <br><br>METHODS: A follow-up was conducted on a cohort of 12 patients with severe ID, undergoing DBS in posteromedial hypothalamic nuclei; evaluated with the Overt Aggression Scale (OAS), before the intervention, at 6, 12, and 18 months of medical follow-up. <br><br>RESULTS: After the surgical procedure, there was a significant reduction in the aggressiveness of patients in the follow-up medical evaluation at 6 months (t = 10.14; p < 0.01), 12 months (t = 14.06; p < 0.01), and 18 months (t = 15.34; p < 0.01), respect to the initial measurement; with a very large effect size (6 months: d = 2.71; 12 months: d = 3.75; 18 months: d = 4.10). From 12 months onward, emotional control stabilized and is sustained at 18 months (t = 1.24; p > 0.05). <br><br>CONCLUSION: DBS in posteromedial hypothalamic nuclei may be an effective treatment for the management of aggression in patients with ID refractory to pharmacological treatment.<p /> <p>Language: en</p>
%G en
%I John Wiley and Sons
%@ 1755-5930
%U http://dx.doi.org/10.1111/cns.14156