%0 Journal Article
%T Prevalence and correlates of lifetime suicide attempt in obsessive-compulsive disorder with major depression
%J Journal of psychiatric research
%D 2023
%A Samuels, Jack
%A Bienvenu, O. Joseph
%A Krasnow, Janice
%A Grados, Marco A.
%A Cullen, Bernadette A.
%A Goes, Fernando S.
%A McLaughlin, Nicole C.
%A Rasmussen, Steven A.
%A Fyer, Abby J.
%A Knowles, James A.
%A McCracken, James T.
%A Geller, Dan
%A Riddle, Mark A.
%A Piacentini, John
%A Stewart, S. Evelyn
%A Greenberg, Benjamin D.
%A Nestadt, Gerald
%A Nestadt, Paul
%V 161
%N 
%P 228-236
%X BACKGROUND: Little is known about specific obsessive-compulsive clinical features associated with lifetime history of suicide attempt in individuals with obsessive-compulsive disorder (OCD) and major depression. <br><br>METHODS: The study sample included 515 adults with OCD and a history of major depression. In exploratory analyses, we compared the distributions of demographic characteristics and clinical features in those with and without a history of attempted suicide and used logistic regression to evaluate the association between specific obsessive-compulsive clinical features and lifetime suicide attempt. <br><br>RESULTS: Sixty-four (12%) of the participants reported a lifetime history of suicide attempt. Those who had attempted suicide were more likely to report having experienced violent or horrific images (52% vs. 30%; p < 0.001). The odds of lifetime suicide attempt were more than twice as great in participants with versus without violent or horrific images (O.R. = 2.46, 95%, CI = 1.45-4.19; p < 0.001), even after adjustment for other risk correlates of attempted suicide, including alcohol dependence, post-traumatic stress disorder, parental conflict, excessive physical discipline, and number of episodes of depression. The association between violent or horrific images and attempted suicide was especially strong in men, 18-29 year olds, those with post-traumatic stress disorder, and those with particular childhood adversities. <br><br>CONCLUSIONS: Violent or horrific images are strongly associated with lifetime suicide attempts in OCD-affected individuals with a history of major depression. Prospective clinical and epidemiological studies are needed to elucidate the basis of this relationship.<p /> <p>Language: en</p>
%G en
%I Elsevier Publishing
%@ 0022-3956
%U http://dx.doi.org/10.1016/j.jpsychires.2023.02.027