%0 Journal Article
%T Texas youth depression and suicide network (TX-YDSRN) research registry and learning healthcare network: rationale, design, and baseline characteristics
%J Journal of affective disorders
%D 2023
%A Trivedi, Madhukar H.
%A Minhajuddin, Abu
%A Slater, Holli
%A Baronia, Regina
%A Blader, Joseph
%A Blood, Jamon
%A Brown, Ryan
%A DeFilippis, Melissa
%A Farmer, David
%A Garza, Cynthia
%A Hughes, Jennifer L.
%A Kennard, Beth D.
%A Liberzon, Israel
%A Martin, Sarah
%A Mayes, Taryn L.
%A Soares, Jair C.
%A Soutullo, Cesar A.
%A Storch, Eric A.
%A Wakefield, Sarah M.
%V ePub
%N ePub
%P ePub-ePub
%X BACKGROUND: American youth are seriously impacted by depression and suicide. The Texas Youth Depression and Suicide Research Network (TX-YDSRN) Participant Registry Study was initiated in 2020 to develop predictive models for treatment outcomes in youth with depression and/or suicidality. This report presents the study rationale, design and baseline characteristics of the first 1000 participants. <br><br>METHODS: TX-YDSRN consists of the Network Hub (coordinating center), 12 medical school "Nodes" (manage/implement study), each with 1-5 primary care, inpatient, and/or outpatient Sub-Sites (recruitment, data collection). Participants are 8-20-year-olds who receive treatment or screen positive for depression and/or suicidality. Baseline data include mood and suicidality symptoms, associated comorbidities, treatment history, services used, and social determinants of health. Subsequent assessments occur every two months for 24 months. <br><br>RESULTS: Among 1000 participants, 68.7 % were 12-17 years, 24.6 % were ≥ 18 years, and 6.7 % were < 12. Overall, 36.8 % were non-Hispanic Caucasian, 73.4 % were female, and 79.9 % had a primary depressive disorder. Nearly half of the sample reported ≥1 suicide attempt, with rates similar in youth 12-17 years old (49.9 %) and those 18 years and older (45.5 %); 29.9 % of children <12 reported at least one suicide attempt. Depression and anxiety scores were in the moderate-severe range for all age groups (Patient Health Questionnaire [PHQ-9]: 12.9 ± 6.4; Generalized Anxiety Disorder [GAD-7]: 11.3 ± 5.9). LIMITATIONS: The sample includes youth who are receiving depression care at enrollment and may not be representative of non-diagnosed, non-treatment seeking youth. <br><br>CONCLUSIONS: The TX-YDSRN is one of the largest prospective longitudinal cohort registries designed to develop predictive models for outcome trajectories based on disorder heterogeneity, social determinants of health, and treatment availability.<p /> <p>Language: en</p>
%G en
%I Elsevier Publishing
%@ 0165-0327
%U http://dx.doi.org/10.1016/j.jad.2023.07.035