%0 Journal Article
%T Epigenomic and transcriptomic alterations in deep-layer pyramidal neurons of individuals who died by suicide with histories of early-life adversity
%J Biological psychiatry
%D 2023
%A Almeida, Daniel
%A Suderman, Matthew
%A Nagy, Corina
%A Mechaward, Naguib
%A Turecki, Gustavo
%V 93
%N 9
%P S38-S39
%X Early-life adversity (ELA) is a major public health concern that significantly increases the lifetime risk for suicide. Deep-layer pyramidal neurons (DLPNs) are important players in the microcircuitry of the PFC, which have been associated with ELA. In the present study we aimed to characterize long-term alterations to the epigenome and transcriptome of DLPNs associated with ELA.<p /> <p>Language: en</p>
%G en
%I Elsevier Publishing
%@ 0006-3223
%U http://dx.doi.org/10.1016/j.biopsych.2023.02.112