%0 Journal Article
%T Association between substance-induced psychosis and suicide attempt: a Danish nation-wide register-based study
%J Addiction
%D 2023
%A Munch, Solvejg Dam
%A Madsen, Trine
%A Nordentoft, Merete
%A Erlangsen, Annette
%A Hjorthøj, Carsten
%V ePub
%N ePub
%P ePub-ePub
%X BACKGROUND AND AIMS: Substance-induced psychosis has previously been linked to an excess risk of suicide; however, the association between substance-induced psychosis and suicide attempt has hitherto not been investigated. We investigated whether substance-induced psychosis was associated with a higher risk of subsequent suicide attempt.
DESIGN: Nation-wide prospective register-based cohort study. SETTING: Denmark. PARTICIPANTS: All people living in Denmark aged 13 years or more during 1995 to 2017. MEASUREMENTS: Substance-induced psychosis and suicide attempts were identified through hospital records as ICD-10 codes.
FINDINGS: A total of 8900 (78.8% males) individuals were diagnosed with a substance-induced psychosis, and 740 of these had a suicide attempt during follow-up. People with a substance-induced psychosis had a higher risk of a subsequent suicide attempt [hazard ratio (HR) = 13.4, 95% confidence interval (CI) = 12.4-14.4] when compared with the general population. The highest hazard ratios were found for psychosis induced by opioids (HR = 26.4, 95% CI = 18.2-38.2); alcohol (HR = 17.7, 95% CI = 15.2-20.6); sedatives (HR = 17.2, 95% CI = 8.9-33.0); and cocaine (HR = 15.6, 95% CI = 10.7-22.8), while cannabis-induced psychosis was linked to an HR of 8.9 (95% CI = 7.7-10.3). Approximately 15% of patients with substance-induced psychosis had had a suicide attempt within 20 years of their substance-induced psychosis diagnosis.
CONCLUSIONS: In Denmark, substance-induced psychosis appears to be strongly associated with subsequent suicide attempt, underscoring the importance of attention and better follow-up for this patient group. Language: en
%G en
%I John Wiley and Sons
%@ 0965-2140
%U http://dx.doi.org/10.1111/add.16311