%0 Journal Article
%T Altered gray matter volumes and plasma IL-6 level in major depressive disorder patients with suicidal ideation
%J Neuroimage: clinical
%D 2023
%A Guo, Yingrui
%A Jiang, Xiaowei
%A Jia, Linna
%A Zhu, Yue
%A Han, Xinyu
%A Wu, Yifan
%A Liu, Wen
%A Zhao, Wenhui
%A Zhu, Huaqian
%A Wang, Dahai
%A Tu, Zhaoyuan
%A Zhou, Yifang
%A Sun, Qikun
%A Kong, Lingtao
%A Wu, Feng
%A Tang, Yanqing
%V 38
%N 
%P e103403-e103403
%X BACKGROUNDS: Suicidal ideation (SI) is one of the most serious consequences of major depressive disorder (MDD). Understanding the unique mechanism of MDD with SI (MDD + S) is crucial for treatment development. While abundant research has studied MDD, past studies have not reached a consensus on the mechanism of MDD + S. The study aimed to investigate the abnormalities of the gray matter volumes (GMVs) and plasma IL-6 level in MDD + S to further reveal the mechanism of MDD + S. <br><br>METHODS: We tested the plasma IL-6 level using Luminex multifactor assays and collected the Structural Magnetic Resonance Imaging (SMRI) data from 34 healthy controls (HCs), 36 MDD patients without SI (MDD - S) and 34 MDD + S patients. We performed a partial correlation between the GMVs of the brain regions with significant differences and plasma IL-6 level with age, sex, medication, scores of HAMD-17 and HAMA as the covariates. <br><br>RESULTS: Compared with HCs and MDD - S, MDD + S had significantly decreased GMVs in the left cerebellum Crus I/II and significantly increased plasma IL-6 level; compared with HCs, both the MDD + S and MDD - S had significantly decreased GMVs in right precentral and postcentral gyri. No significant correlation was found between the GMVs and the plasma IL-6 level in the MDD + S and MDD - S, respectively. While the GMVs of the right precentral and postcentral gyri negatively correlated with the level of IL-6 in the whole MDD (r = -0.28, P = 0.03). The GMVs of the left cerebellum Crus I/II (r = -0.47, P = 0.02), and the right precentral and postcentral gyri (r = -0.42, P = 0.04) negatively correlated with the level of IL-6 in HCs. <br><br>CONCLUSION: The altered GMVs and the plasma IL-6 level may provide a scientific basis to understand the pathophysiological mechanisms of MDD + S.<p /> <p>Language: en</p>
%G en
%I Elsevier Publishing
%@ 2213-1582
%U http://dx.doi.org/10.1016/j.nicl.2023.103403