%0 Journal Article
%T Serotonin transporter gene ( 5-HTT ) polymorphism and major depressive disorder in patients in Bogotá, Colombia
%J Biomedica: Revista del Instituto Nacional de Salud
%D 2016
%A Pérez Olmos, Isabel
%A Bustamante, Delia
%A Ibáñez Pinilla, Milcíades
%V 36
%N 2
%P 285-294
%X INTRODUCTION: The 5-HTT short allele has been controversially associated with an increased risk of major depressive disorder. <br><br>OBJECTIVE: To determine the association of 5-HTT short allele with major depression in Bogotá, Colombia. <br><br>MATERIALS AND METHODS: We carried out a study of cases (n=68) matched 1:1 with controls by gender and age (±5 years). Major depression was diagnosed using the Mini-International Neuropsychiatric Interview, and 5-HTT polymorphism using PCR. <br><br>RESULTS: Females were predominant (82.4%). The S (short) allele predominated in cases compared with controls (S: 72.1% vs. 63.2; L (long): 27.9% vs. 36.8%), and the SL genotype was more frequent in cases (SL: 45.6% vs. 36.8%; LL: 27.9% vs. 36.8%; SS: 26.5% vs. 26.5%), although not significantly. There were significant differences in those under age 37, with a predominance of the S allele in cases (p=0.038; OR=2.75; 95% CI: 0.88-8.64). Multivariate analysis, adjusted for comorbid anxiety disorders, showed a significant association of major depression with the SL genotype (p=0.049; OR=3.20; 95% CI: 1.00-10.23); the S allele was close to statistical significance (p=0.063; OR=2.94; 95% CI: 0.94-9.13), and it was statistically significant in cases under 37 years of age (p=0.026; OR=10.79; 95% CI: 1.32-80.36). <br><br>CONCLUSIONS: The SL genotype was associated with major depressive disorder in patients of all ages. The S allele was significantly associated with major depressive disorder in patients under age 37, adjusted for comorbid anxiety disorders.<p /><p>Language: en</p>
%G en
%I Instituto Nacional de Salud (Colombia)
%@ 0120-4157
%U http://dx.doi.org/10.7705/biomedica.v36i3.3014