%0 Journal Article %T Alterations in Brain Serotonin Synthesis in Male Alcoholics Measured Using Positron Emission Tomography %J Alcoholism: clinical and experimental research %D 2009 %A Nishikawa, Masami %A Diksic, Mirko %A Sakai, Yojiro %A Kumano, Hiroaki %A Charney, Dara %A Palacios‐Boix, Jorge %A Negrete, Juan %A Gill, Kathryn %V 33 %N 2 %P 233-239 %X Background:  A consistent association between low endogenous 5HT function and high alcohol preference has been observed, and a number of serotonergic manipulations (uptake blockers, agonists) alter alcohol consumption in animals and humans. Studies have also shown an inverse relationship between alcohol use and cerebrospinal fluid levels of serotonin metabolites, suggesting that chronic alcohol consumption produces alterations in serotonin synthesis or release.

%G %I John Wiley and Sons %@ 0145-6008 %U http://dx.doi.org/10.1111/j.1530-0277.2008.00820.x