%0 Journal Article %T GC-MS and IR Studies on the six ring regioisomeric dimethoxyphenylpiperazines (DOMePPs) %J Journal of forensic sciences %D 2014 %A Abdel-Hay, Karim M. %A DeRuiter, Jack %A Clark, C. Randall %V 60 %N 2 %P 285-294 %X A number of N-substituted piperazines have been described as drugs of abuse in recent years. This new drug category includes several series of aromatic ring substituted phenylpiperazines. The wide variety of available precursors makes regioisomerism a significant issue in these totally synthetic compounds. In this study, a complete series of regioisomeric dimethoxyphenylpiperazines were synthesized and evaluated using GC-MS and FT-IR. The EI mass spectra show fragments characteristic of both the dimethoxyphenyl and the piperazine portions of the molecules including the dimethoxyphenylaziridinium cation (m/z 180) and dimethoxyphenyl cation (m/z 137). The ion at m/z 56 for the C3 H6 N(+) fragment is characteristic of the piperazine ring and was observed in all the spectra. The perfluoroacyl derivatives were resolved by GC, and their mass spectra showed some differences in relative abundance of ions. FTIR provides direct confirmatory data for differentiation between the regioisomeric dimethoxyphenylpiperazines, and GC separation was accomplished on an Rtx-200 phase.

Language: en

%G en %I John Wiley and Sons %@ 0022-1198 %U http://dx.doi.org/10.1111/1556-4029.12668