%0 Journal Article %T Modification of the risk of post-traumatic stress disorder (PTSD) by the 5-HTTLPR polymorphisms after Lorca's earthquakes (Murcia, Spain) %J Psychiatry research %D 2019 %A Navarro-Mateu, Fernando %A Escámez, Teresa %A Quesada, M. Paz %A Alcaráz, M. José %A Vilagut, Gemma %A Salmerón, Diego %A Huerta, José M. %A Chirlaque, M. Dolores %A Navarro, Carmen %A Kessler, Ronald C. %A Alonso, Jordi %A Martínez, Salvador %V ePub %N ePub %P ePub-ePub %X Information of the modulation effect of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) on post-traumatic stress disorder (PTSD) after earthquakes is scarce and contradictory. A cross-sectional face-to-face interview survey of a representative sample of the adults was carried out after the Lorca (Spain) earthquakes (May 11, 2011). Socio-demographic variables, DSM-IV diagnostic assessment and earthquake-related stressors were obtained from the Composite International Diagnostic Interview (CIDI). The triallelic and biallelic classification of the 5-HTTLPR polymorphism were genotyped from buccal swabs. Multivariate logistic regression models were used to predict PTSD, including interaction terms to explore gene-environment (G x E) interactions. The vast majority (83%, n = 341) of the Lorca survey respondents (n = 412, 71% response rate) were genotyped. Both classifications of the 5-HTTLPR genotype were in Hardy-Weinberg equilibrium. Prior lifetime PTSD was the only variable that remained a significant predictor after adjustments. There were no significant main effects of earthquake related stressors or 5-HTTLPR. However, G x E interactions of 5-HTTLPR with high emotional impact and prior lifetime anxiety disorders were statistically significant. These results provide new evidence of the modulation effect of the 5-HTTLPR polymorphisms on PTSD risk. This information might characterize people at higher risk of developing PTSD after an earthquake exposure.

Copyright © 2019. Published by Elsevier B.V.

Language: en

%G en %I Elsevier Publishing %@ 0165-1781 %U http://dx.doi.org/10.1016/j.psychres.2019.112640