TY  - JOUR
PY  - 2008//
TI  - Periventricular white matter hyperintensities as predictors of suicide attempts in bipolar disorders and unipolar depression
JO  - Progress in neuro-psychopharmacology and biological psychiatry
A1  - Pompili, Maurizio
A1  - Innamorati, Marco
A1  - Mann, J. John
A1  - Oquendo, Maria A.
A1  - Lester, David
A1  - Del Casale, Antonio
A1  - Serafini, Gianluca
A1  - Rigucci, Silvia
A1  - Romano, Andrea
A1  - Tamburello, Antonino
A1  - Manfredi, Giovanni
A1  - De Pisa, Eleonora
A1  - Ehrlich, Stefan
A1  - Giupponi, Giancarlo
A1  - Amore, Mario
A1  - Tatarelli, Roberto
A1  - Girardi, Paolo
SP  - 1501
EP  - 1507
VL  - 32
IS  - 6
N2  - The aim of this study was to evaluate whether deep white matter hyperintensities (DWMH) and periventricular white matter hyperintensities (PVH) are associated with suicidal behavior in patients with major affective disorders. Subjects were 99 consecutively admitted inpatients (42 men; 57 women; mean age: 46.5 years [SD=15.2; Min./Max.=19/79]) with a diagnosis of major affective disorder (bipolar disorder type I, bipolar disorder type-II and unipolar major depressive disorder). 44.4% of the participants had made at least one previous suicide attempt. T2-weighted brain magnetic resonance images were rated for the presence and extension of WMH using the modified Fazekas scale. Patients were interviewed for clinical data on average 5 days after admission. Bivariate analyses, corrected for multiple-testing, and logistic regression analysis were used to test the association between suicide attempts and clinical variables. Attempters and nonattempters differed only in the presence of PVH--the former were more likely to have PVH. The logistic regression indicated that the presence of PVH was robustly associated with suicidal behaviors after controlling for age (OR: 8.08). In conclusion, neuroimaging measures may be markers of risk for suicidal attempts in patients with major affective disorders.<p />  <p>Language: en</p>
LA  - en
SN  - 0278-5846
UR  - http://dx.doi.org/10.1016/j.pnpbp.2008.05.009
ID  - ref1
ER  -