TY  - JOUR
PY  - 2008//
TI  - Altered serotonin 2C receptor RNA splicing in suicide: association with editing
JO  - Neuroreport
A1  - Dracheva, S.
A1  - Chin, Benjamin
A1  - Haroutunian, V.
SP  - 379
EP  - 382
VL  - 19
IS  - 3
N2  - In an earlier study, we showed increases in serotonin 2C receptor (5-HT2CR) pre-mRNA editing in prefrontal cortex that were specific to suicide victims irrespective of associated psychiatric diagnoses. Here we demonstrate that the ratio between the two 5-HT2CR splice variants is increased in people who committed suicide, but does not vary among the diagnostic groups. This provides further evidence for suicide-specific neurobiology and suggests that, as it was previously shown in vitro, 5-HT2CR editing modulates its splicing in human brain. The association analysis indicates, however, that the efficiency of 5-HT2CR editing is an imperfect predictor of the splicing outcome, and that splice site selection is only partially controlled by the level of editing in vivo.<p />  <p>Language: en</p>
LA  - en
SN  - 0959-4965
UR  - http://dx.doi.org/10.1097/WNR.0b013e3282f556d2
ID  - ref1
ER  -