TY  - JOUR
PY  - 2008//
TI  - Life-threatening valproate overdose successfully treated with haemodialysis
JO  - Arhiv za higijenu rada i toksikologiju
A1  - Mestrović, Julije
A1  - Filipovic, Tomislav
A1  - Polić, Branka
A1  - Stricević, Luka
A1  - Omazić, Ante
A1  - Kuzmanić-Samija, Radenka
A1  - Markić, Josko
SP  - 295
EP  - 298
VL  - 59
IS  - 4
N2  - Valproate (VPA) poisoning is an increasing clinical problem. The most common finding in VPA overdose is the depression of the central nervous system, which may progress to coma and death. This type of poisoning is difficult to treat, as no antidote exists. This report describes a case with a 16-year-old girl who poisoned herself with valproate. Initial treatment included naloxone, but she did not respond. She became comatose, with serum VPA concentration of 1320 microg mL(-1). Three sessions of haemodialysis were performed, effectively eliminating VPA and decreasing the serum concentration. The patient regained consciousness and fully recovered.To our knowledge, this is the highest serum VPA concentration reported by now in children aged 16 or less. Haemodialysis has proved to be the treatment of choice for life-threatening acute VPA overdose in children.<p />  <p>Language: en</p>
LA  - en
SN  - 0004-1254
UR  - http://dx.doi.org/10.2478/10004-1254-59-2008-1884
ID  - ref1
ER  -