TY  - JOUR
PY  - 2007//
TI  - Tachykinin receptor 1 variants associated with aggression in suicidal behavior
JO  - American journal of medical genetics. part B, neuropsychiatric genetics
A1  - Giegling, Ina
A1  - Rujescu, Dan
A1  - Mandelli, Laura
A1  - Schneider, Birke
A1  - Hartmann, Annette M.
A1  - Schnabel, Axel
A1  - Maurer, Konrad
A1  - De Ronchi, Diana
A1  - Moller, Hans-Jurgen
A1  - Serretti, Alessandro
SP  - 757
EP  - 761
VL  - 144B
IS  - 6
N2  - Substance P is involved in the modulation of depression, anxiety, and suicidal-related behaviors. We studied gene variants of Tachykinin Receptor 1 (TACR1-rs3771810, rs3771825, rs726506, rs1477157) in 167 German suicide attempters (affective spectrum n = 107, schizophrenia spectrum n = 35, borderline personality disorder n = 25), 92 Caucasian individuals who committed suicide and 312 German healthy subjects. Single markers and haplotype analysis in relation to suicidal behaviors (suicide attempters/completers) did not reveal any significant association. The rarest rs3771825 T allele however showed a marginal association with higher Reactive Aggression scores on the Questionnaire for Measuring Factors of Aggression (FAF) (F = 9.86, df = 1; P = 0.0017). Haplotype analyses confirmed the finding. Violence or impulsivity of suicide attempt and State-Trait Anger Expression Inventory (STAXI) scores were not associated with gene variants. In conclusion, our study suggests that TACR1 gene variants have no major influence on suicidal behavior but may modulate aggression features.<p /> <p>Language: en</p> 
LA  - en
SN  - 1552-4841
UR  - http://dx.doi.org/10.1002/ajmg.b.30506
ID  - ref1
ER  -