TY - JOUR PY - 2009// TI - Acute intentional self-poisoning with a herbicide product containing fenoxaprop-P-ethyl, ethoxysulfuron, and isoxadifen ethyl: a prospective observational study JO - Clinical toxicology (Philadelphia, Pa.) A1 - Zawahir, Shukry A1 - Roberts, Darren M. A1 - Palangasinghe, Chathura A1 - Mohamed, Fahim A1 - Eddleston, Michael A1 - Dawson, A. H. A1 - Buckley, Nicholas A. A1 - Ren, Leigh A1 - Medley, Gregory A. A1 - Gawarammana, Indika SP - 792 EP - 797 VL - 47 IS - 8 N2 - Background. Herbicides are commonly ingested for self-harm, but relatively little has been published on poisoning with herbicides other than paraquat and glyphosate. We report here a case series of patients with acute exposure to a product containing the selective phenoxy herbicide compounds fenoxaprop-P-ethyl and ethoxysulfuron and a safener isoxadifen ethyl. Method. Clinical data on all patients presenting with Tiller Gold or Whip Super poisoning to two General Hospitals in Sri Lanka from 2002-2008 were collected prospectively until discharge. Results. Eighty-six patients with a history of Tiller Gold or Whip Super ingestion were included. The main clinical features were an epigastric burning sensation and vomiting; however, most of those who vomited had received gastric lavage or forced emesis. Eight patients had a reduced level of consciousness on admission (Glasgow coma scale 9-14) that resolved without intervention over several hours. Only symptomatic and supportive care was required. The median hospital stay was 1 day (IQR: 1-2) and the case fatality was zero (95% confidence interval: 0-4.2%). This low case fatality compared favorably with the case fatality of other common herbicides in our cohort: paraquat >40%, propanil >10%, 4-chloro-2-methylphenoxyacetic acid > 5%, and glyphosate >2%. Conclusion. This combination herbicide product appears to be safe in patients with acute self-poisoning, particularly in comparison with other herbicides, and causing few clinical features.

Language: en

LA - en SN - 1556-3650 UR - http://dx.doi.org/10.1080/15563650903174810 ID - ref1 ER -