TY  - JOUR
PY  - 2006//
TI  - Association study between the novel functional polymorphism of the serotonin transporter gene and suicidal behaviour in schizophrenia
JO  - European Neuropsychopharmacology
A1  - De Luca, Vincenzo
A1  - Zai, Gwyneth C.
A1  - Tharmalingam, Subi
A1  - de Bartolomeis, Andrea
A1  - Wong, Greg
A1  - Kennedy, James L.
SP  - 268
EP  - 271
VL  - 16
IS  - 4
N2  - A serotonin transporter gene linked polymorphic region (5-HTTLPR) has been investigated in several genetic association studies, including studies of schizophrenia and suicidality. The current study was designed to examine whether the new long (A/G) variant polymorphism of the 5-HTT gene may be associated with suicide attempts of 290 Caucasian schizophrenic patients. Among these patients, 92 had a history of suicide attempt. No association with history of suicide attempt was found in the multiallelic 5-HTTLPR (p = 0.305), however we found significant association with the intron 2 VNTR polymorphism (p = 0.018). When we performed a haplotype analysis, we found association between suicide attempt and haplotype distribution (p = 0.031). These findings suggest that the intron 2 VNTR polymorphism in serotonin transporter gene may influence suicidal behaviour in schizophrenia.<p />  <p>Language: en</p>
LA  - en
SN  - 0924-977X
UR  - http://dx.doi.org/10.1016/j.euroneuro.2005.09.007
ID  - ref1
ER  -