TY  - JOUR
PY  - 2006//
TI  - alpha-11CMethyl-L-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters
JO  - European Neuropsychopharmacology
A1  - Leyton, Marco
A1  - Paquette, Vincent
A1  - Gravel, Paul
A1  - Rosa-Neto, Pedro
A1  - Weston, Francine
A1  - Diksic, Mirko
A1  - Benkelfat, Chawki
SP  - 220
EP  - 223
VL  - 16
IS  - 3
N2  - Low serotonin neurotransmission is thought to increase vulnerability to suicidal behavior. To test this hypothesis, we measured brain regional serotonin synthesis, as indexed by PET and alpha-(11)Cmethyl-L-tryptophan trapping, in 10 patients who had made a high-lethality suicide attempt and 16 healthy controls. Compared to healthy controls, suicide attempters had reduced normalized alpha-(11)Cmethyl-L-tryptophan trapping in orbital and ventromedial prefrontal cortex. alpha-(11)CMethyl-L-tryptophan trapping in these regions correlated negatively with suicide intent. Low serotonin synthesis in the prefrontal cortex might lower the threshold for suicidal behavior.<p />  <p>Language: en</p>
LA  - en
SN  - 0924-977X
UR  - http://dx.doi.org/10.1016/j.euroneuro.2005.09.006
ID  - ref1
ER  -