TY - JOUR PY - 1982// TI - Neuroendocrine risk factors of suicidal behavior JO - American journal of psychiatry A1 - Ostroff, R. A1 - Giller, E. Jr A1 - Bonese, K. A1 - Ebersole, E. A1 - Harkness, L. A1 - Mason, Jacquelyn SP - 1323 EP - 1325 VL - 139 IS - 10 N2 - Three of 22 subjects in a study of neuroendocrine correlates of clinical change made serious suicide attempts, 2 of which were lethal. The suicidal subjects had significantly higher 24-hour urinary cortisol levels and significantly lower 24-hour urinary norepinephrine-to-epinephrine ratios than the nonsuicidal patients had. Although the cortisol finding confirms earlier reports, the norepinephrine-to-epinephrine ratio finding is new. The results support the concept that the clinical utility of neuroendocrine measures is enhanced by using a multihormonal profile.

Language: en

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