TY  - JOUR
PY  - 1983//
TI  - 5-hydroxytryptamine and depression: a model for the interaction of normal variance with pathology
JO  - British journal of clinical pharmacology
A1  - Goodwin, Frederick K.
A1  - Post, R. M.
SP  - 393S
EP  - 405S
VL  - 15
IS  - Suppl 3
N2  - 1 Theories linking 5-hydroxytryptamine (5-HT) with depression are briefly reviewed. The various experimental strategies adopted to investigate this relationship, examination of autopsy data, CSF metabolite data, 5-HT re-uptake patterns in human blood platelets and imipramine binding studies in human platelets, are discussed. 2 Recent studies of 5-hydroxyindole acetic acid (5-HIAA) levels in cerebrospinal fluid have revealed a linkage between low 5-HIAA levels and suicide, aggression and impulsivity. Decreases in the number of imipramine binding sites have also been found in brains of suicide victims. 3 The available data lead to the conclusion that decreased 5-hydroxytryptaminergic function may be associated with an increased risk of depression, suicide, and some types of aggression.<p />  <p>Language: en</p>
LA  - en
SN  - 0306-5251
UR  - http://dx.doi.org/
ID  - ref1
ER  -