TY  - JOUR
PY  - 1990//
TI  - Regionally selective increases in mu opioid receptor density in the brains of suicide victims
JO  - Brain research
A1  - Gross-Isseroff, R.
A1  - Dillon, K. A.
A1  - Israeli, M.
A1  - Biegon, A.
SP  - 312
EP  - 316
VL  - 530
IS  - 2
N2  - The effect of ageing and suicide on mu opioid receptors was studied in the human brain postmortem. Quantitative autoradiography with 3H.DAGO revealed region specific increases in mu receptor density with age. Suicide was accompanied by a significant increase, up to 9-fold, in mu receptor density in the young, but not the old, subjects as compared to age-matched controls. This effect was evident in the frontal and temporal cortical gyri. Saturation binding studies with the same ligand show that the increased binding in the elderly and in the young suicides is due to an increase in receptor density (Bmax) rather than affinity (Kd).<p />  <p>Language: en</p>
LA  - en
SN  - 0006-8993
UR  - http://dx.doi.org/
ID  - ref1
ER  -