TY  - JOUR
PY  - 1991//
TI  - Peripheral serotonergic markers in patients with suicidal behavior
JO  - European Neuropsychopharmacology
A1  - Simonsson, P.
A1  - Träskman-Bendz, Lil
A1  - Alling, C.
A1  - Oreland, Lars
A1  - Regnell, G.
A1  - Ohman, R.
SP  - 503
EP  - 510
VL  - 1
IS  - 4
N2  - Peripheral serotonergic parameters were studied in 17 patients with a history of suicidal behavior and in 17 age- and sex-matched healthy controls. Serotonin2 receptor function in platelets, measured as serotonin-induced 32P.phosphatidylinositol 4,5-bisphosphate hydrolysis, was significantly higher in patients than in age- and sex-matched controls. Increased serotonin2 receptor transduction was not correlated to psychiatric diagnosis, drug treatment or a history of violent suicide attempt. Monoamine oxidase activity was lower in platelets from patients with a history of suicidal behavior than in controls. In addition, whole blood serotonin was analyzed but no significant alterations were found in blood from patients.<p />  <p>Language: en</p>
LA  - en
SN  - 0924-977X
UR  - http://dx.doi.org/
ID  - ref1
ER  -