TY  - JOUR
PY  - 1991//
TI  - Diltiazem overdose: pharmacokinetics of diltiazem and its metabolites and effect of multiple dose charcoal therapy
JO  - Journal of toxicology - clinical toxicology
A1  - Roberts, D.
A1  - Honcharik, N.
A1  - Sitar, D. S.
A1  - Tenenbein, Milton
SP  - 45
EP  - 52
VL  - 29
IS  - 1
N2  - We describe a 38 year-old female who ingested 900 mg of diltiazem. She experienced hypotension, bradycardia and heart block but responded well to supportive care that included normal saline infusion and vasopressors. Calcium administration was not beneficial. Serial plasma concentrations of diltiazem, N-demethyldiltiazem and desacetyldiltiazem were quantified. By comparing the elimination half-life for diltiazem with historical controls, it is concluded that multiple dose charcoal therapy was not beneficial for our patient.<p />  <p>Language: en</p>
LA  - en
SN  - 0731-3810
UR  - http://dx.doi.org/
ID  - ref1
ER  -