TY  - JOUR
PY  - 1992//
TI  - Alterations in monoamine receptors in the brain of suicide victims
JO  - Journal of clinical psychopharmacology
A1  - Arango, V.
A1  - Underwood, Mark D.
A1  - Mann, J. John
SP  - 8S
EP  - 12S
VL  - 12
IS  - 2 Suppl
N2  - Suicide has been linked to alterations in the serotonergic and noradrenergic systems. Using in vitro quantitative receptor autoradiography, we compared the binding of 125I-lysergic acid diethylamide (5-hydroxytryptamine-2 sites) and 125I-pindolol (beta-adrenergic sites) with slide-mounted sections from the prefrontal and the temporal cortex of a group of suicide victims, matched to control specimens on postmortem interval, age, sex, and race. A specific laminar distribution of 5-hydroxytryptamine-2 binding was found in both groups, with layers III and IV having the highest level of binding, but beta-adrenergic binding did not differ across cortical layers. Binding to both 125I-lysergic acid diethylamide and 125I-pindolol was increased in the prefrontal cortex of the suicide victims, whereas only beta-adrenergic binding was increased in the temporal cortex of the suicide group.<p />  <p>Language: en</p>
LA  - en
SN  - 0271-0749
UR  - http://dx.doi.org/
ID  - ref1
ER  -