TY  - JOUR
PY  - 1993//
TI  - NMDA glutamatergic receptors, labelled with 3H.MK-801, in brain samples from drug-free depressed suicides
JO  - Brain research
A1  - Holemans, S.
A1  - De Paermentier, F.
A1  - Horton, R. W.
A1  - Crompton, M. R.
A1  - Katona, C. L.
A1  - Maloteaux, J. M.
SP  - 138
EP  - 143
VL  - 616
IS  - 1-2
N2  - Glutamate receptors of the NMDA-subtype were quantitated by binding of 3H.dizocilpine maleate (MK-801) in nine brain regions from 22 suicide victims (20-60 yr), with a firm retrospective diagnosis of depression, who had not recently received antidepressant drugs, and 20 age- and sex-matched controls. 3H.MK-801-binding did not differ between suicides and controls in any region studied. Suicides who died violently did not differ from non-violent suicides and controls. A significative negative correlation was found between age and NMDA receptor-binding in the frontal cortex of suicide victims, but not in controls. This preliminary study provides little evidence for an important role of NMDA-binding sites in the pathophysiology of depression.<p />  <p>Language: en</p>
LA  - en
SN  - 0006-8993
UR  - http://dx.doi.org/
ID  - ref1
ER  -