TY  - JOUR
PY  - 2010//
TI  - Interpretation of neuropathological lesions: Its limitations in medico-legal experts' reports
JO  - Forensic science international
A1  - Piercecchi-Marti, Marie-Dominique
A1  - De Paula, Andre Maues
A1  - Gavaudan, Gilles
A1  - Bartoli, Christophe
A1  - Pélissier-Alicot, Anne-Laure
A1  - Léonetti, Georges
A1  - Pellissier, Jean-Francois
SP  - e1
EP  - 3
VL  - 194
IS  - 1-3
N2  - Aggressive or paradoxical behaviour may reflect an organic dementia. The most frequent is Alzheimer's disease, which results from an abnormal structural conformation of tubulin-associated protein (tau) and beta-amyloid protein that, respectively, aggregate in certain neurons as intracellular neurofibrillary tangles (NFTs) and in the extracellular environment as senile plaques. These lesions progress in the brain tissue according to the stages described by Braak and Braak. Staging of neurofibrillary pathology has proven anatomical and clinical correlation, which can be used in a medico-legal procedure. We report two cases demonstrating discrepancies between anatomical and clinical features, which should encourage medical expert to prudence when interpreting neuropathological reports.<p />  <p>Language: en</p>
LA  - en
SN  - 0379-0738
UR  - http://dx.doi.org/10.1016/j.forsciint.2009.07.010
ID  - ref1
ER  -