TY  - JOUR
PY  - 2005//
TI  - Plasma serotonin levels and suicidal behavior in adolescents
JO  - European Neuropsychopharmacology
A1  - Tyano, Sam
A1  - Zalsman, Gil
A1  - Ofek, H.
A1  - Blum, Ilanan
A1  - Apter, Alan
A1  - Wolovik, Luisa
A1  - Sher, Leo
A1  - Sommerfeld, Eliane
A1  - Harell, Daniella
A1  - Weizman, Abraham
SP  - 49
EP  - 57
VL  - 16
IS  - 1
N2  - To evaluate the relationship between plasma serotonin (p5-HT) levels and psychometric measures in suicidal adolescents vs. controls, 211 adolescents from three sites in Israel were divided into four groups: suicidal psychiatric inpatients (n=35); non-suicidal psychiatric inpatients (n=30); adolescents referred to the emergency room (ER) due to a suicide attempt (n=51); and a community-based control group from 4 high schools in the same catchment areas (n=95). All were interviewed and assessed for violence, aggression, depression, impulsivity, anger, anxiety, and p5-HT. p5-HT levels were significantly lower in the control group compared to all other groups. A significant negative correlation was found between p5-HT level and suicidal behavior severity among the suicidal inpatients. p5-HT did not discriminate between the psychiatric diagnostic categories and was significantly lower in ER violent compared to non-violent subjects. Gender, depression, and anger were associated with suicidal behavior in all four groups. Beck Depression Inventory (BDI) scores together with p5-HT levels discriminated between healthy controls and other groups. p5-HT level in combination with some of the psychometric scales may serve as a safe and inexpensive peripheral marker of psychopathology, and may help to differentiate between sub-populations of suicidal adolescents. The biological mechanism behind the serotonin dysregulation in suicidal adolescents requires further investigation.
LA  - 
SN  - 0924-977X
UR  - http://dx.doi.org/10.1016/j.euroneuro.2005.05.005
ID  - ref1
ER  -