TY  - JOUR
PY  - 2009//
TI  - Clinical and model research of neurotrauma
JO  - Methods in molecular biology
A1  - Büki, Andras
A1  - Kövesdi, Erzsebet
A1  - Pal, Jozsef
A1  - Czeiter, Endre
SP  - 41
EP  - 55
VL  - 566
IS  - 
N2  - Modeling traumatic brain injury represents a major challenge for neuroscientists - to represent extremely complex pathobiological processes kept under close surveillance in the most complex organ of a laboratory animal. To ensure that such models also reflect those alterations evoked by and/or associated with traumatic brain injury (TBI) in man, well-defined, graded, simple injury paradigms should be used with clear endpoints that also enable us to assess the relevance of our findings to human observations. It is of particular importance that our endpoints should harbor clinical significance, and to this end, biological markers ultimately associated with the pathological processes operant in TBI are considered the best candidate. This chapter provides protocols for relevant experimental models of TBI and clinical materials for neuroproteomic analysis.<p />  <p>Language: en</p>
LA  - en
SN  - 1064-3745
UR  - http://dx.doi.org/10.1007/978-1-59745-562-6_3
ID  - ref1
ER  -