TY  - JOUR
PY  - 2005//
TI  - Family-based association study of 5-HT(2A) receptor T102C polymorphism and suicidal behavior in Ashkenazi inpatient adolescents
JO  - International journal of adolescent medicine and health
A1  - Zalsman, Gil
A1  - Frisch, Amos
A1  - Baruch-Movshovits, Ruth
A1  - Sher, Leo
A1  - Michaelovsky, Elena
A1  - King, Robert A.
A1  - Fischel, Tsvi
A1  - Hermesh, Haggai
A1  - Goldberg, Pablo
A1  - Gorlyn, Marianne
A1  - Misgav, Sagit
A1  - Apter, Alan
A1  - Tyano, Sam
A1  - Weizman, Abraham
SP  - 231
EP  - 238
VL  - 17
IS  - 3
N2  - Suicidal behavior runs in families and is partially genetically determined. Since greater serotonin 5-HT(2A) receptor binding has been reported in postmortem brain and platelets of suicide victims, the 5-HT(2A) receptor gene polymorphism T102C became one of the candidate sites in the study of suicide and impulsive-aggressive traits. However, studies that examined the association of this polymorphism with suicidality have contradictory results. This study used a family-based method and one homogenous ethnic group to overcome ethnic stratification in order to test this association. METHODS: Thirty families of inpatient adolescents from Jewish Ashkenazi origin, with a recent suicide attempt, were genotyped. All subjects were interviewed for clinical diagnosis, depressive and impulsive-aggressive traits and demographic data. Allele frequencies were assessed using the Haplotype Relative Risk method for trios. RESULTS: No difference was found in allelic distribution between transmitted and non-transmitted alleles. There was no significant association of genotype with any of the clinical traits CONCLUSIONS: These preliminary results suggest that the 5-HT(2A) T102C polymorphism is unlikely to be associated with suicidal behavior and related traits in adolescent suicide attempters.<p />  <p>Language: en</p>
LA  - en
SN  - 0334-0139
UR  - http://dx.doi.org/
ID  - ref1
ER  -