TY  - JOUR
PY  - 2010//
TI  - Impulsivity, gender, and the platelet serotonin transporter in healthy subjects
JO  - Neuropsychiatric disease and treatment
A1  - Marazziti, Donatella
A1  - Baroni, Stefano
A1  - Masala, Irene
A1  - Golia, Francesca
A1  - Consoli, Giorgio
A1  - Massimetti, Gabriele
A1  - Picchetti, Michela
A1  - Dell'osso, Mario Catena
A1  - Giannaccini, Gino
A1  - Betti, Laura
A1  - Lucacchini, Antonio
A1  - Ciapparelli, Antonio
SP  - 9
EP  - 15
VL  - 6
IS  - 
N2  - The present study explored the possible relationships between impulsivity, gender, and a peripheral serotonergic marker, the platelet serotonin (5-HT) transporter (SERT), in a group of 32 healthy subjects. The impulsivity was measured by means of the Barratt Impulsivity Scale, version 11 (BIS-11), a widely used self-report questionnaire, and the platelet SERT was evaluated by means of the specific binding of (3)H-paroxetine ((3)H-Par) to platelet membranes, according to standardized protocols. The results showed that women had a higher BIS-11 total score than men, and also higher scores of two factors of the same scale: the motor impulsivity and the cognitive complexity. The analysis of the correlations revealed that the density of the SERT proteins, as measured by the maximum binding capacity (B(max)) of (3)H-Par, was significantly and positively related to the cognitive complexity factor, but only in men. Men showed also a significant and negative correlation with the dissociation constant, Kd, of ((3)H-Par) binding, and the motor impulsivity factor. These findings suggest that women are generally more impulsive than men, but that the 5-HT system is more involved in the impulsivity of men than in that of women.<p />  <p>Language: en</p>
LA  - en
SN  - 1176-6328
UR  - http://dx.doi.org/
ID  - ref1
ER  -