TY  - JOUR
PY  - 2010//
TI  - Lacosamide intoxication in attempted suicide
JO  - Epilepsy and behavior
A1  - Bauer, Sebastian
A1  - Rudd, G. David
A1  - Mylius, Veit
A1  - Hamer, Hajo M.
A1  - Rosenow, Felix
SP  - 549
EP  - 551
VL  - 17
IS  - 4
N2  - The anticonvulsant drug lacosamide selectively enhances slow inactivation of voltage-gated sodium channels and has been shown to be an effective add-on treatment for partial-onset seizures. Common adverse events (frequency 10%) of lacosamide doses up to 600mg/day include nonspecific central nervous system effects (e.g., dizziness, ataxia, diplopia, and somnolence). There are no human data regarding the safety of very high dosages of lacosamide. We report the clinical course of a patient with bitemporal epilepsy who ingested 12g of lacosamide, 56g of gabapentin, 2g of topiramate, and 2.8g of zonisamide during a suicide attempt. The patient was found comatose and experienced repeated generalized tonic-clonic seizures, aspiration with subsequent pneumonia, hypotension, and an increase in PR interval. Complete physical recovery occurred after several days of supportive treatment. We conclude that intoxication with lacosamide, in combination with overdoses of multiple AEDs, can be survived without sequelae, even after ingestion of 12g lacosamide.<p />  <p>Language: en</p>
LA  - en
SN  - 1525-5050
UR  - http://dx.doi.org/10.1016/j.yebeh.2010.01.007
ID  - ref1
ER  -