TY  - JOUR
PY  - 2010//
TI  - Evidence for Two Concurrent Inhibitory Mechanisms during Response Preparation
JO  - Journal of neuroscience
A1  - Duque, Julie
A1  - Lew, David
A1  - Mazzocchio, Riccardo
A1  - Olivier, Etienne
A1  - Ivry, Richard B.
SP  - 3793
EP  - 3802
VL  - 30
IS  - 10
N2  - Inhibitory mechanisms are critically involved in goal-directed behaviors. To gain further insight into how such mechanisms shape motor representations during response preparation, motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) and H-reflexes were recorded from left hand muscles during choice reaction time tasks. The imperative signal, which indicated the required response, was always preceded by a preparatory cue. During the postcue delay period, left MEPs were suppressed when the left hand had been cued for the forthcoming response, suggestive of a form of inhibition specifically directed at selected response representations. H-reflexes were also suppressed on these trials, indicating that the effects of this inhibition extend to spinal circuits. In addition, left MEPs were suppressed when the right hand was cued, but only when left hand movements were a possible response option before the onset of the cue. Notably, left hand H-reflexes were not modulated on these trials, consistent with a cortical locus of inhibition that lowers the activation of task-relevant, but nonselected responses. These results suggest the concurrent operation of two inhibitory mechanisms during response preparation: one decreases the activation of selected responses at the spinal level, helping to control when selected movements should be initiated by preventing their premature release; a second, upstream mechanism helps to determine what response to make during a competitive selection process.<p />  <p>Language: en</p>
LA  - en
SN  - 0270-6474
UR  - http://dx.doi.org/10.1523/JNEUROSCI.5722-09.2010
ID  - ref1
ER  -