TY  - JOUR
PY  - 2010//
TI  - Pharmacokinetics of biological tags in a case of acute valpromide self poisoning
JO  - Annales de Biologie Clinique
A1  - Commandeur, Diane
A1  - Danguy Des Deserts, Marc
A1  - Giacardi, Christophe
A1  - Eyrieux, Sandrine
A1  - Ould-Ahmed, Mehdi
A1  - Drouillard, Isabelle
SP  - 234
EP  - 238
VL  - 68
IS  - 2
N2  - We report the case of a 35-year-old woman hospitalized in intensive care unit after valpromide self-poisoning (Dépamide(R)). The dose supposed to be taken was 15 g. The patient eleven hours after ingestion, presented, a coma with bilateral non-reactive mydriasis, justifying intubation and mechanical ventilation. An acidosis (pH = 7.24), a hyperlactatemia (2.72 mmol/L), a hyperammonemia (328.9 mumol/L), and were diagnosed valproic acid plasmatic concentration was 1190 mug/mL at 22 hours. Symptomatic treatment and L-carnitine therapy (50 mg/kg/12h) normalized the action of biological abnormalities and allowed disappearance of symptoms; the patient was extubated after 46 hours, and outcome from intensive care unit at 65 hours.<p />  <p>Language: fr</p>
LA  - fr
SN  - 0003-3898
UR  - http://dx.doi.org/10.1684/abc.2010.0421
ID  - ref1
ER  -