TY  - JOUR
PY  - 2010//
TI  - Mild intellectual disability associated with a progeny of father-daughter incest: genetic and environmental considerations
JO  - Journal of child sexual abuse
A1  - Ansermet, Francois
A1  - Lespinasse, James
A1  - Gimelli, Stefania
A1  - Béna, Frederique
A1  - Paoloni-Giacobino, Ariane
SP  - 337
EP  - 344
VL  - 19
IS  - 3
N2  - We report the case of a 34-year-old female resulting from a father-daughter sexual abuse and presenting a phenotype of mild intellectual disability with minor dysmorphic features. Karyotyping showed a normal 46, XX constitution. Array-based comparative genomic hybridization (array-CGH) revealed a heterozygote 320kb 6p22.3 microdeletion in the proband, encompassing only one known gene, and therefore unlikely to be the cause of the phenotype. However, the role of other genetic factors, such as a recessive condition, could not be ruled out as a putative cause for the phenotype. On the other hand, the role played by a heavily detrimental familial situation on the development and outcome, and possibly leading or contributing to a mild intellectual disability, should be taken into account.<p />  <p>Language: en</p>
LA  - en
SN  - 1053-8712
UR  - http://dx.doi.org/10.1080/10538711003788991
ID  - ref1
ER  -