TY  - JOUR
PY  - 2010//
TI  - Early stress is associated with alterations in the orbitofrontal cortex: a tensor-based morphometry investigation of brain structure and behavioral risk
JO  - Journal of neuroscience
A1  - Hanson, Jamie L.
A1  - Chung, Mina K.
A1  - Avants, Brian B.
A1  - Shirtcliff, Elizabeth A.
A1  - Gee, James C.
A1  - Davidson, R. J.
A1  - Pollak, Seth D.
SP  - 7466
EP  - 7472
VL  - 30
IS  - 22
N2  - Individuals who experience early adversity, such as child maltreatment, are at heightened risk for a broad array of social and health difficulties. However, little is known about how this behavioral risk is instantiated in the brain. Here we examine a neurobiological contribution to individual differences in human behavior using methodology appropriate for use with pediatric populations paired with an in-depth measure of social behavior. We show that alterations in the orbitofrontal cortex among individuals who experienced physical abuse are related to social difficulties. These data suggest a biological mechanism linking early social learning to later behavioral outcomes.<p />  <p>Language: en</p>
LA  - en
SN  - 0270-6474
UR  - http://dx.doi.org/10.1523/JNEUROSCI.0859-10.2010
ID  - ref1
ER  -