TY - JOUR PY - 1994// TI - Prolonged penile erections induced by hydroxyzine: possible mechanism of action JO - Neuropsychobiology A1 - Thavundayil, J. X. A1 - Hambalek, R. A1 - Kin, N. M. A1 - Krishnan, B. A1 - Lal, Sara SP - 4 EP - 6 VL - 30 IS - 1 N2 - We describe a subject who developed prolonged penile erections on hydroxyzine. Molecular modelling showed that the hydroxyzine metabolite, norchlorcyclizine, has structural and conformational similarities to the trazodone metabolite, m-chlorophenylpiperazine. This suggests that a common pharmacological mechanism may underlie the ability of trazodone and hydroxyzine to induce erections.
Language: en
LA - en SN - 0302-282X UR - http://dx.doi.org/ ID - ref1 ER -