TY  - JOUR
PY  - 1995//
TI  - Influence of antemortem medication on the determination of brain death
JO  - Nippon Hoigaku Zasshi
A1  - Saito, T.
A1  - Takeichi, S.
A1  - Nakajima, Y.
A1  - Yukawa, Nobuhiro
A1  - Osawa, M.
SP  - 484
EP  - 487
VL  - 49
IS  - 6
N2  - Post-mortem concentration of pentobarbital in the blood and brain of two deceased neurosurgical patients was determined by gas chromatography/mass spectrometry. Patients treated with barbiturate for elevated intracranial pressure after head injury may incur brain death. In the present two cases of brain death a large amount of barbiturate remained in the brain, even when the blood concentration was not detectable, possibly because the blood flow was stagnant in the brain. It is suggested that a patient under barbiturate coma should be given serious consideration as to the determination of brain death, even if barbiturate is negative in the blood.<p /> <p>Language: en</p> 
LA  - en
SN  - 0047-1887
UR  - http://dx.doi.org/
ID  - ref1
ER  -