TY  - JOUR
PY  - 2008//
TI  - Modeling "frailty": can a simple feedback model suffice?
JO  - Mechanisms of ageing and development
A1  - Yates, F. Eugene
SP  - 671
EP  - 672
VL  - 129
IS  - 11
N2  - This commentary offers several views of frailty, and provides an excerpt of the dynamic model proposed by Varadhan et al., noting that it is of a traditional, causal feedback type. Key features of the authors' model are examined, and some limitations identified. (Other more modern approaches are suggested, but not expanded.) In spite of its simplicity, the deterministic feedback model as presented does indicate that weakened connectivity among feedback loops is a possible basis of frailty. In contrast, a nodal-network style of modeling might emphasize nodal failure as well as (or instead of) connectivity failure as the dynamic signature of frailty.<p /> <p>Language: en</p> 
LA  - en
SN  - 0047-6374
UR  - http://dx.doi.org/10.1016/j.mad.2008.09.015
ID  - ref1
ER  -