TY  - JOUR
PY  - 1996//
TI  - Abnormalities in behavior, learning ability, and the cholinergic system induced by long-term ultraviolet A irradiation of mice
JO  - Neuropsychobiology
A1  - Hiramoto, K.
A1  - Okada, Tomoko
A1  - Ito, M.
SP  - 182
EP  - 185
VL  - 33
IS  - 4
N2  - Behavioral abnormalities, jumping reaction, increase in spontaneous activity abnormal violence, and lethargy were observed in long-term ultraviolet A (UVA)-irradiated hairy male Crj:CD-1 mice. The learning ability of 6- and 12-months UVA-irradiated mice was significantly reduced compared to un-irradiated age-matched mice. Acetylcholine levels, acetylcholinesterase and choline acetyltransferase activities in the whole brains were decreased in both of 6- and 12-month irradiated mice. Only 1 of 6 mice irradiated for 12 months was histologically observed to have a drastic loss of bilateral hippocampal pyramidal cells in the CA1 field of Ammon's horn.<p /> <p>Language: en</p> 
LA  - en
SN  - 0302-282X
UR  - http://dx.doi.org/
ID  - ref1
ER  -