TY  - JOUR
PY  - 2010//
TI  - Longitudinal characterization of motor and cognitive deficits in a model of penetrating ballistic-like brain injury
JO  - Journal of neurotrauma
A1  - Shear, Deborah A.
A1  - Lu, Xi-Chun May
A1  - Bombard, Matthew C.
A1  - Pedersen, Rebecca
A1  - Chen, Zhiyong
A1  - Davis, Abigail
A1  - Tortella, Frank C.
SP  - 1911
EP  - 1923
VL  - 27
IS  - 10
N2  - Traumatic brain injury (TBI) produces a wide range of motor and cognitive changes. While some neurological symptoms may respond to therapeutic intervention during the initial recovery period, others may persist for many years after the initial insult and often have a devastating impact on quality of life for the TBI victim. The aim of the current study was to develop neurobehavioral testing parameters designed to provide a longitudinal assessment of neurofunctional deficits in a rodent model of penetrating ballistic-like brain injury (PBBI). We report here a series of experiments where unilateral frontal PBBI was induced in rats, and motor/cognitive abilities were assessed in a battery of tests ranging from 30 min to 10 weeks post injury. Results showed that PBBI produced consistent and significant (1) neurological deficits (neuroscore examination: 30 min to 10 weeks post-PBBI), (2) sensorimotor dysfunction in the contralateral forelimb (forelimb asymmetry task: 7 and 21 days), (3) motor dysfunction (balance beam task: 3-7 days; and fixed-speed rotarod task: 3-28 days), and (4) spatial learning deficits in the Morris water maze (MWM) task out to 10 weeks post-injury. Overall, the results of the present study demonstrate that PBBI produces enduring motor and cognitive deficits and identifies the optimal task and testing parameters for facilitating longitudinal screening of promising therapeutic interventions in this brain injury model.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2010.1399
ID  - ref1
ER  -