TY  - JOUR
PY  - 2007//
TI  - Effect of annual intramuscular vitamin D on fracture risk in elderly men and women--a population-based, randomized, double-blind, placebo-controlled trial
JO  - Rheumatology (Oxford)
A1  - Smith, H.
A1  - Anderson, Fiona
A1  - Raphael, H.
A1  - Maslin, P.
A1  - Crozier, S.
A1  - Cooper, Colin
SP  - 1852
EP  - 1857
VL  - 46
IS  - 12
N2  - OBJECTIVES: Low trauma fractures in older people incur enormous physical, social and economic costs. Previous research indicates that an annual intramuscular injection of vitamin D may reduce fracture rates in this group. This strategy requires validation in a population setting. METHODS: Randomized, double-blind, placebo-controlled trial of 300,000 IU intramuscular (i.m.) vitamin D2 (ergocalciferol) injection or matching placebo every autumn over 3 years. 9440 people (4354 men and 5086 women) aged 75 yrs and over were recruited from general practice registers in Wessex, England. Primary outcome measure was all non-vertebral fracture. Secondary outcomes were hip and wrist fractures, and all falls. RESULTS: 585 subjects had incident non-spine fractures (hip 110, wrist 116, ankle 37). Hazard ratios (HRs) for fracture in the vitamin D group were: 1.09 [95% confidence interval (CI) 0.93-1.28, P = 0.29] for any first fracture, 1.49 (95% CI 1.02-2.18, P = 0.04) for hip and 1.22 (95% CI 0.85-1.76, P = 0.28) for wrist. There was no effect on falls: HR 0.98 (0.93-1.04). No protective effect was observed in any subgroup when the cohort was stratified by sex, age, previous fracture or mobility. CONCLUSIONS: An annual i.m. injection of 300,000 IU vitamin D2 is not effective in preventing non-vertebral fractures among elderly men and women resident in the general population.<p /> <p>Language: en</p> 
LA  - en
SN  - 1462-0324
UR  - http://dx.doi.org/10.1093/rheumatology/kem240
ID  - ref1
ER  -