TY  - JOUR
PY  - 2011//
TI  - Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents
JO  - Addiction biology
A1  - Desrivières, S
A1  - Lourdusamy, Anbarasu
A1  - Muller, Christopher
A1  - Ducci, Francesca
A1  - Wong, Cybele P.
A1  - Kaakinen, Marika
A1  - Pouta, Anneli
A1  - Hartikainen, Anna-Liisa
A1  - Isohanni, Matti
A1  - Charoen, Pimphen
A1  - Peltonen, Leena
A1  - Freimer, Nelson
A1  - Elliott, Peter
A1  - Järvelin, Marjo-Riitta
A1  - Schumann, Gunter
SP  - 510
EP  - 513
VL  - 16
IS  - 3
N2  - Onset of alcohol use at an early age increases the risk for later alcohol dependence. We investigated the role of the glucocorticoid receptor (GR) gene (NR3C1) in onset of alcohol use and abuse in 14-year-old adolescents (n = 4534). Several NR3C1 polymorphisms were associated with onset of alcohol drinking or drunkenness at this age. Strongest associations were observed in females, with one marker (rs244465) remaining significant after correction for multiple testing (P(adj) = 0.0067; odds ratio = 1.7, for drunkenness). Our data provide the first evidence that GR modulates initiation of alcohol abuse and reveal a polymorphism that might contribute to susceptibility to addiction.<p />  <p>Language: en</p>
LA  - en
SN  - 1355-6215
UR  - http://dx.doi.org/10.1111/j.1369-1600.2010.00239.x
ID  - ref1
ER  -