TY  - JOUR
PY  - 2007//
TI  - Determination of tetrodotoxin and its analogs in the puffer fish Takifugu oblongus from Bangladesh by hydrophilic interaction chromatography and mass-spectrometric detection
JO  - Analytical and bioanalytical chemistry
A1  - Diener, Marc
A1  - Christian, B.
A1  - Ahmed, M. Sagir
A1  - Luckas, Bernd
SP  - 1997
EP  - 2002
VL  - 389
IS  - 6
N2  - Tetrodotoxin (TTX) and its analogs (TTXs), widely distributed among marine as well as terrestrial animals, induce dangerous intoxications. These highly potential toxins are also known as the causative agent of puffer fish poisoning. A newly developed highly sensitive method for determination of TTXs based on hydrophilic interaction chromatography and mass-spectrometric detection is presented. TTX, anhydrotetrodotoxin, 11-deoxytetrodotoxin and trideoxytetrodotoxin were determined in separated tissues of Bangladeshi marine puffers, Takifugu oblongus. TTX was predominant in skin, muscle and liver, whereas trideoxytetrodotoxin preponderated in the ovary. The toxicity of the various tissues was determined by a mouse bioassay.<p /> <p>Language: en</p> 
LA  - en
SN  - 1618-2642
UR  - http://dx.doi.org/10.1007/s00216-007-1602-7
ID  - ref1
ER  -