TY  - JOUR
PY  - 2009//
TI  - Intoxication after extreme oral overdose of quetiapine to attempt suicide: pharmacological concerns of side effects
JO  - Case reports in medicine
A1  - Muller, Christopher
A1  - Reuter, H.
A1  - Dohmen, C.
SP  - ID 371698
EP  - ID 371698
VL  - 2009
IS  - online
N2  - Quetiapine is an atypical antipsychotic approved for the treatment of patients with psychotic disorders. Since approvement several case reports about intoxication with quetiapine were linked mainly with tachycardia, QT(c)-prolongation, somnolence, and hyperglycemia. Here, we present the first case report of an intoxication with an extreme overdose of quetiapine (36 g), ingested by a 32-year-old female (62 kg bodyweight) to attempt suicide. Symptoms associated with intoxication were coma without arterial hypotension, persistent tachycardia, hyperglycemia, and transient hypothyreoidism. QT(c)-interval was moderately extended. Management consisted of intubation for airway protection, gastric lavage, the use of activated charcoal, i.v. saline, and observation for 17 hours on an intensive care unit. Despite the extremely high dose of quetiapine, the patient recovered completely without residual symptoms.<p />  <p>Language: en</p>
LA  - en
SN  - 1687-9627
UR  - http://dx.doi.org/10.1155/2009/371698
ID  - ref1
ER  -