TY  - JOUR
PY  - 2011//
TI  - Intraspecies variability in Vipera ammodytes ammodytes venom related to its toxicity and immunogenic potential
JO  - Comparative Biochemistry and Physiology, C: Toxicology and Pharmacology
A1  - Halassy, Beata
A1  - Brgles, Marija
A1  - Habjanec, Lidija
A1  - Balija, Maja Lang
A1  - Kurtović, Tihana
A1  - Marchetti-Deschman, Martina
A1  - Krizaj, Igor
A1  - Allmaier, Günter
SP  - 223
EP  - 230
VL  - 153
IS  - 2
N2  - Vipera ammodytes is the most venomous European snake, whose venom has been used as antigen for immunization of antivenom-producing animals. Same as venom of any other snake, it is a complex mixture of proteins, peptides and other compounds which biochemical and pharmacological variability has been demonstrated at inter- and intraspecies level. In this work we demonstrated intraspecific variability between 8 venom production batches using both the conventional and the new methodology. Moreover, in contrast to literature on different venoms' variability, for the first time we were able to select those biochemical differences that are related to and give information on the venom's toxicity and immunogenicity. We have shown that methods quantifying ammodytoxin (the most toxic compound identified so far in the Vipera ammodytes ammodytes venom) content of the venom clearly distinguish between high and low immunogenic venoms.<p />  <p>Language: en</p>
LA  - en
SN  - 1532-0456
UR  - http://dx.doi.org/10.1016/j.cbpc.2010.10.007
ID  - ref1
ER  -