TY  - JOUR
PY  - 2010//
TI  - Sudden-Onset Tachypnea and Confusion in a Previously Healthy Teenager
JO  - Therapeutic drug monitoring
A1  - Glatstein, Miguel
A1  - Garcia-Bournissen, Facundo
A1  - Scolnik, Dennis
A1  - Rosenbloom, Ehud
A1  - Koren, Gideon
SP  - 700
EP  - 703
VL  - 32
IS  - 6
N2  - Acute intoxication with acetylsalicylic acid is a severe event commonly seen in children resulting from wide availability of this drug without prescription. Cases of self-poisoning resulting from overdose continue to occur and, although far less common, they are often severe and life-threatening. We report a 14-year-old girl who presented to the emergency department with tachypnea and altered mental status as a result of acetylsalicylic acid overdose in a suicide attempt. We discuss her presentation and the pathophysiological considerations leading to the management decisions taken during her emergency department stay, highlighting the role of the clinician and therapeutic drug monitoring consultant. The use of rapid decontamination with multiple doses of charcoal, even when more than 4 hours have passed since ingestion, and the use of urinary alkalinization are stressed. Timely management can obviate the need for dialysis. Published cases of acetylsalicylic acid intoxication are reviewed.<p />  <p>Language: en</p>
LA  - en
SN  - 0163-4356
UR  - http://dx.doi.org/10.1097/FTD.0b013e3181fa5936
ID  - ref1
ER  -