TY  - JOUR
PY  - 2003//
TI  - Pharmacological management of aggression and violence
JO  - Human psychopharmacology
A1  - Humble, F.
A1  - Berk, M.
SP  - 423
EP  - 436
VL  - 18
IS  - 6
N2  - The pharmacological management of violence and aggression is a common and substantial clinical dilemma in the emergency psychiatric situation. A literature search was conducted through PubMed and using the Cochrane Library. This was followed by a manual search of selected literature. Randomised controlled trials were sought that specifically addressed the acute situation, rather than the ongoing management of chronic conditions. There was a paucity of well-controlled data and insufficient evidence to support the use of many agents in emergency situations. Many studies had considerable limitations making comparison difficult. Efficacy data for a range of treatment options exists, including the use of classical and atypical anti-psychotic agents, benzodiazepines and combination therapies. Clinical risk, tolerability and environmental factors need to form part of a careful and considered judgement in the choice of treatment. Safety, tolerability and the potential for a positive experience are major considerations, thus paving the way for long term compliance.<p /> <p>Language: en</p> 
LA  - en
SN  - 0885-6222
UR  - http://dx.doi.org/10.1002/hup.504
ID  - ref1
ER  -