TY  - JOUR
PY  - 1995//
TI  - A reliable method for the detection, confirmation, and quantitation of cannabinoids in blood
JO  - Journal of analytical toxicology
A1  - Goodall, C. R.
A1  - Basteyns, B. J.
SP  - 419
EP  - 426
VL  - 19
IS  - 6
N2  - A sensitive and reliable method was developed for the identification and quantitation of cannabinoids in blood. Samples were screened by fluorescence polarization immunoassay. Analysis was completed on a benchtop mass selective detector using selected ion monitoring. The limits of detection were 0.2 ng/mL for delta9-tetrahydrocannabinol (THC and 11-hydroxy-THC and 2 ng/mL for 11-nor-9-carboxy-THC. Extensive method validation is presented, including within-run variation, between-run variation, and results from external proficiency testing. Sample stability was studied over a 6-month period. Several derivatives and extraction techniques were evaluated to determine optimum performance. Data from a blind study of 217 samples were used to determine the predictive value of the screening procedure. The procedure is used routinely in the laboratory on samples from drivers issued a citation for impaired driving and also on postmortem blood from death investigations.    Keywords: Cannabis impaired driving  <p />  <p>Language: en</p>
LA  - en
SN  - 0146-4760
UR  - http://dx.doi.org/
ID  - ref1
ER  -