TY  - JOUR
PY  - 1995//
TI  - Anxiolytics' effects on the actual driving performance of patients and healthy volunteers in a standardized test. An integration of three studies
JO  - Neuropsychobiology
A1  - O'Hanlon, J. F.
A1  - Vermeeren, A.
A1  - Uiterwijk, M. M.
A1  - van Veggel, L. M.
A1  - Swijgman, H. F.
SP  - 81
EP  - 88
VL  - 31
IS  - 2
N2  - Effects of benzodiazepine (diazepam, lorazepam) and benzodiazepine-like anxiolytics (alpidem, suriclone) and a 5-HT-3 antagonist (ondansetron) on actual driving performance were measured in three double-blind, placebo-controlled studies. Subjects were healthy volunteers in two and anxious patients in the third. Treatments lasted for 8 days. Standardized testing occurred within the first full day and on the last day of treatment. No important differences existed between volunteers' and patients' baseline and/or placebo performances and both groups responded similarly to comparable drugs/doses. Benzodiazepine and benzodiazepine-like anxiolytics produced marked and pervasive driving impairment, which lasted throughout treatment; but ondansetron, none.<p /> <p>Language: en</p> 
LA  - en
SN  - 0302-282X
UR  - http://dx.doi.org/
ID  - ref1
ER  -