TY  - JOUR
PY  - 2010//
TI  - Chemical Constituents of the Bark of Dipteryx alata Vogel, an Active Species against Bothrops jararacussu Venom
JO  - Molecules
A1  - Puebla, Pilar
A1  - Oshima-Franco, Yoko
A1  - Franco, Luiz M.
A1  - dos Santos, Marcio G.
A1  - Silva, Renata V. da
A1  - Rubem-Mauro, Leandro
A1  - Feliciano, Arturo San
SP  - 8193
EP  - 8204
VL  - 15
IS  - 11
N2  - The effect of four sub-extracts prepared from the lyophilized hydroalcoholic bark of Dipteryx alata (Leguminosae-Papilionoideae) dissolved in a methanol-water (80:20) mixture through a liquid-liquid partition procedure has been investigated against the neuromuscular blockade of the venom of the snake Bothrops jararacussu. The active CH(2)Cl(2) sub-extract has been extensively analyzed for its chemical constituents, resulting in the isolation of four lupane-type triterpenoids: lupeol (1), lupenone (2), 28-hydroxylup-20(29)-en-3-one (3), betulin (4), nine isoflavonoids: 8-O-methylretusin (5), 7-hydroxy-5,6,4'-trimethoxyisoflavone (6), afrormosin (8), 7-hydroxy-8,3',4'-trimethoxyisoflavone (9), 7,3'-dihydroxy-8,4'-dimethoxyisoflavone (10), odoratin (11), 7,8,3'-trihydroxy-4'-methoxyisoflavone (13), 7,8,3'-trihydroxy-6,4'-dimethoxyisoflavone (15), dipteryxin (17), one chalcone: isoliquiritigenin (7), one aurone: sulfuretin (14) and three phenolic compounds: vanillic acid (12), vanillin (16), and protocatechuic acid (18). Their chemical structures were elucidated on the basis of spectroscopic analysis, including HRMS, 1D- and 2D-NMR techniques.<p />  <p>Language: en</p>
LA  - en
SN  - 1420-3049
UR  - http://dx.doi.org/10.3390/molecules15118193
ID  - ref1
ER  -